The pathophysiology of fibromyalgia is not fully understood, but research suggests it is a disorder of central pain processing, resulting in amplification of pain signals and altered pain perception. Here are some of the proposed mechanisms based on the latest research:

1. Central Sensitization: This is a condition where the central nervous system gets into a persistent state of high reactivity. This lowers the threshold for what causes pain and can result in a heightened sensitivity to pain (allodynia) and a more intense and prolonged pain experience (hyperalgesia).

2. Neurotransmitter Dysregulation: Studies have found abnormal levels of neurotransmitters such as serotonin, norepinephrine, and substance P in people with fibromyalgia, which are implicated in pain regulation.

3. Neuroendocrine Abnormalities: Alterations in the hypothalamic-pituitary-adrenal (HPA) axis and abnormal levels of certain hormones, such as cortisol, which are involved in the stress response, may contribute to the symptoms.

4. Genetic Factors: There's evidence suggesting fibromyalgia may have a genetic component, as it often runs in families, and specific genetic markers are associated with the condition.

5. Sleep Disturbances: Patients with fibromyalgia often have sleep disorders, such as restless legs syndrome or sleep apnea. Poor sleep can exacerbate pain and fatigue.

6. Immune System Dysregulation: Some research has suggested that there may be an immunological aspect to fibromyalgia, with certain inflammatory markers being elevated.

7. Functional and Structural Brain Changes: Imaging studies have shown changes in blood flow to certain areas of the brain, alterations in brain structure, and differences in how the brain processes pain signals.

8. Small Fiber Polyneuropathy (SFPN): Some fibromyalgia patients exhibit features of SFPN, which involves the dysfunction and damage to small fibers of the peripheral nervous system.

9. Psychological Factors: Psychological stress can exacerbate fibromyalgia symptoms and may be involved in the development of the condition for some individuals.

Each of these factors may interplay differently in different individuals, making the disease presentation quite heterogeneous. Research continues to evolve in this field, and a multidisciplinary approach is often required to manage this complex condition.

Currently, the treatment of fibromyalgia is still largely symptomatic, focusing on managing pain, improving sleep, and maintaining function. Based on the latest research and clinical guidelines, some of the most effective treatment strategies include combining the following therapies:

1. Medication: Certain medications have been found to be helpful in reducing symptoms, including:

- Pain relievers: Over-the-counter pain relievers are sometimes used, but they are often not effective on their own.

- Antidepressants: Duloxetine (Cymbalta) and milnacipran (Savella) may help ease pain and fatigue.

- Anticonvulsants: Medications designed to treat epilepsy, such as pregabalin (Lyrica) and gabapentin (Neurontin), are often used in fibromyalgia treatment to reduce pain.

2. Exercise: Regular physical activity increases muscle strength, endurance, and aerobic fitness, and can reduce fibromyalgia symptoms. A graded exercise program starting slowly and gradually increasing can be beneficial.

3. Cognitive Behavioral Therapy (CBT): This form of talk therapy can help manage the pain, depression, and anxiety associated with fibromyalgia.

4. Multidisciplinary Approaches: Combining chiropractic, physical therapy, massage therapy, counselling, medication, and patient education can be more effective than any single treatment alone.

5. Stress-Reduction Techniques: Mindfulness-based stress reduction, yoga, tai chi, and other relaxation techniques can help reduce symptoms.

6. Sleep Management: Proper sleep hygiene can improve sleep quality, which may reduce pain and fatigue.

7. Dietary Adjustments: Although no specific diet is recommended, some individuals may benefit from eating a balanced diet and possibly eliminating certain foods that they find exacerbate their symptoms.

8. Education: Patient education about the condition can empower individuals to understand and manage their symptoms better.

It's essential for patients to work closely with their healthcare providers to tailor a treatment plan to their individual needs, as the effectiveness of treatments can vary greatly among individuals. Regular follow-up is crucial to monitor the condition and adjust treatments as necessary.