Headaches and migraines are common conditions affecting a significant portion of the population. Understanding the differences between them, their underlying causes, and the necessary diagnostic tests is crucial for effective management and treatment. This guide provides a thorough overview of headaches and migraines, including their types, pathophysiology, possible triggers, and recommended tests to find the root causes.

Differences Between a Headache and a Migraine

Headache

Definition: A headache is a pain or discomfort in the head or face area. It can vary in intensity, location, and duration.

Types:

1. Tension Headache: Characterized by a constant, dull ache on both sides of the head. It may feel like a tight band around the forehead.

2. Cluster Headache: Severe, burning pain around one eye or one side of the head, occurring in clusters over weeks or months.

3. Sinus Headache: Associated with sinus infections, causing pain in the forehead, cheeks, and bridge of the nose.

Causes:

• Stress

• Muscle tension

• Eye strain

• Poor posture

• Sinus infections

• Dehydration

• Hunger

• Lack of sleep

Symptoms:

• Mild to moderate pain

• Pressure or tightness in the forehead or sides of the head

• Pain that is usually not aggravated by routine physical activity

Migraine

Definition: A migraine is a neurological condition characterized by intense, debilitating headaches. It often involves other symptoms and can significantly affect daily activities.

Types:

1. Migraine with Aura: Includes sensory disturbances (auras) such as visual changes, tingling, or speech difficulties before the headache phase.

2. Migraine without Aura: More common type, occurring without the sensory disturbances preceding the headache.

Causes:

• Genetics

• Hormonal changes (e.g., menstrual cycle)

• Certain foods and drinks (e.g., alcohol, caffeine, aged cheeses)

• Stress

• Sensory stimuli (e.g., bright lights, loud sounds)

• Sleep changes

• Physical exertion

Symptoms:

• Moderate to severe throbbing or pulsating pain, usually on one side of the head

• Nausea and vomiting

• Sensitivity to light, sound, and sometimes smell

• Visual disturbances (e.g., seeing flashing lights or blind spots)

• Dizziness or vertigo

• Can last from a few hours to several days

• Often aggravated by physical activity

Pathophysiology of Headaches

Tension Headache

• Muscle Tension: The primary underlying mechanism is believed to be the contraction of muscles in the neck and scalp due to stress or poor posture.

• Central Sensitization: Chronic tension headaches might involve changes in the central nervous system, where the brain becomes more sensitive to pain signals over time.

Cluster Headache

• Hypothalamus Activation: The hypothalamus, a region in the brain that controls circadian rhythms, is thought to play a crucial role. Abnormal activation leads to the release of neuropeptides and neurotransmitters.

• Trigeminal Autonomic Reflex: Involves the trigeminal nerve and autonomic nervous system, causing severe pain and autonomic symptoms like tearing and nasal congestion.

Sinus Headache

• Sinus Inflammation: Caused by inflammation of the sinus cavities, often due to infection. This inflammation leads to increased pressure and pain in the sinus areas.

• Mucus Accumulation: The accumulation of mucus and the subsequent blockage of sinus drainage pathways contribute to the pain.

Pathophysiology of Migraines

Cortical Spreading Depression (CSD)

• Wave of Neural Activity: A wave of intense neural activity spreads across the cortex, followed by a period of neural suppression. This phenomenon is believed to be responsible for the aura phase in migraines.

• Ionic and Metabolic Changes: CSD leads to changes in ion concentrations (e.g., potassium and calcium) and metabolic changes in brain cells, contributing to the headache phase.

Trigeminovascular System Activation

• Trigeminal Nerve Involvement: The trigeminal nerve, which provides sensation to the face and head, becomes activated and releases neuropeptides like calcitonin gene-related peptide (CGRP), which cause vasodilation and inflammation of blood vessels.

• Neurogenic Inflammation: The release of these neuropeptides leads to inflammation of the meninges (the protective layers surrounding the brain) and blood vessels, contributing to the pain.

Central Sensitization

• Increased Pain Sensitivity: Repeated migraine attacks can lead to changes in the brainstem and other areas of the central nervous system, resulting in increased sensitivity to pain (central sensitization).

• Allodynia: This central sensitization can cause allodynia, where normally non-painful stimuli (like touching the skin) are perceived as painful.

Genetic Factors

• Genetic Predisposition: Migraines often run in families, indicating a genetic component. Specific genetic mutations and variations can predispose individuals to migraines.

• Ion Channel Dysfunction: Genetic mutations affecting ion channels in neurons can lead to abnormal neuronal excitability, contributing to the initiation of migraines.

Vascular Changes

• Vasodilation: Initial theories focused on vasodilation (widening of blood vessels) as a primary cause of migraines. While vasodilation does occur, it is now understood to be one part of a more complex process involving neural and vascular components.

• Blood-Brain Barrier Disruption: Inflammation and vascular changes can affect the integrity of the blood-brain barrier, contributing to the cascade of events leading to a migraine attack.

Types of Headaches

1. Tension Headache:

• Explanation: Characterized by a dull, aching pain on both sides of the head. It often feels like a tight band around the forehead.

• Who is Likely to Suffer: Common in adults and adolescents; often triggered by stress, anxiety, poor posture, or muscle tension.

2. Cluster Headache:

• Explanation: Severe, burning pain around one eye or one side of the head, occurring in clusters over weeks or months.

• Who is Likely to Suffer: More common in men than women, typically between the ages of 20 and 50.

3. Sinus Headache:

• Explanation: Pain in the forehead, cheeks, and bridge of the nose due to inflamed sinuses.

• Who is Likely to Suffer: Individuals with sinus infections, allergies, or chronic sinusitis.

4. Rebound Headache:

• Explanation: Also known as medication-overuse headache, caused by frequent use of headache medications.

• Who is Likely to Suffer: People who use headache pain relievers (e.g., ibuprofen, aspirin) frequently.

5. Hormone Headache:

• Explanation: Related to hormonal fluctuations, often occurring before or during menstruation, pregnancy, or menopause.

• Who is Likely to Suffer: Women, particularly those experiencing significant hormonal changes.

6. Caffeine Withdrawal Headache:

• Explanation: Caused by sudden reduction or cessation of caffeine intake.

• Who is Likely to Suffer: Individuals who consume large amounts of caffeine regularly.

7. Exertional Headache:

• Explanation: Triggered by physical activity, such as exercise or sexual activity.

• Who is Likely to Suffer: Athletes or people engaging in vigorous physical activities.

8. Hypertension Headache:

• Explanation: Occurs when blood pressure is extremely high.

• Who is Likely to Suffer: Individuals with uncontrolled hypertension (high blood pressure).

9. Ice Pick Headache:

• Explanation: Sudden, sharp, stabbing pain usually lasting a few seconds.

• Who is Likely to Suffer: People with a history of migraines or cluster headaches.

10. Spinal Headache:

• Explanation: Caused by a leak of cerebrospinal fluid after a spinal tap or epidural.

• Who is Likely to Suffer: Individuals who have undergone lumbar punctures or epidural anesthesia.

11. Thunderclap Headache:

• Explanation: A severe headache that peaks within 60 seconds, potentially indicating a serious underlying condition.

• Who is Likely to Suffer: Can affect anyone but requires immediate medical attention due to possible serious causes.

Types of Migraines

1. Migraine with Aura (Classic Migraine):

• Explanation: Preceded by sensory disturbances (auras) such as visual changes, tingling, or speech difficulties before the headache phase.

• Who is Likely to Suffer: Individuals with a family history of migraines; often begins in adolescence or early adulthood.

2. Migraine without Aura (Common Migraine):

• Explanation: Characterized by severe, throbbing headache without preceding sensory disturbances.

• Who is Likely to Suffer: More common than migraine with aura; affects people with similar risk factors as those with aura.

3. Chronic Migraine:

• Explanation: Occurs on 15 or more days per month for more than three months.

• Who is Likely to Suffer: Individuals with a history of episodic migraines, often those who overuse headache medications.

4. Hemiplegic Migraine:

• Explanation: Causes temporary paralysis or sensory changes on one side of the body.

• Who is Likely to Suffer: Often runs in families, affecting individuals with a genetic predisposition.

5. Retinal Migraine:

• Explanation: Temporary visual loss or blindness in one eye, typically lasting less than an hour, followed by a migraine headache.

• Who is Likely to Suffer: Rare, affecting those with a history of migraines, often younger women.

6. Menstrual Migraine:

• Explanation: Occurs in women around their menstrual cycle due to hormonal changes.

• Who is Likely to Suffer: Women of childbearing age, particularly those with significant menstrual hormonal fluctuations.

7. Vestibular Migraine:

• Explanation: Involves vertigo, dizziness, and balance issues, often without a severe headache.

• Who is Likely to Suffer: Individuals with a history of migraines and vestibular (balance) issues.

8. Basilar Migraine:

• Explanation: Affects the brainstem, causing symptoms like double vision, dizziness, and coordination problems.

• Who is Likely to Suffer: More common in adolescents and young adults, especially women.

Co-occurrence of Headaches and Migraines

Common Pathways and Triggers:

• Both headaches and migraines can share common triggers such as stress, lack of sleep, dehydration, and certain foods. These shared triggers can lead to the simultaneous occurrence of both conditions.

• The trigeminal nerve plays a central role in both tension-type headaches and migraines. Activation of this nerve can contribute to pain in both conditions.

Central Sensitization:

• Central sensitization refers to an increased sensitivity of the central nervous system to pain signals. It is a phenomenon where repeated or severe pain can make the nervous system more sensitive to pain stimuli.

• In individuals with chronic migraines, central sensitization can lower the threshold for experiencing other types of headaches, such as tension headaches.

Medication Overuse:

• Overuse of pain medications to treat either migraines or headaches can lead to rebound headaches. This can create a cycle where treating one condition inadvertently exacerbates the other.

How One Can Trigger the Other

1. Tension Headache Triggering a Migraine:

• Muscle Tension: A tension headache caused by muscle tension in the neck and scalp can increase overall head pain, potentially triggering a migraine in individuals predisposed to migraines.

• Stress Response: The stress and discomfort of a tension headache can activate the body’s stress response, leading to the release of stress hormones and neurotransmitters that can trigger a migraine.

2. Migraine Triggering a Tension Headache:

• Postdrome Phase: After a migraine attack (during the postdrome phase), individuals may experience lingering symptoms such as muscle soreness and tension, which can lead to a tension-type headache.

• Neurovascular Changes: The neurovascular changes and inflammation that occur during a migraine can lead to muscle tension and subsequent tension headaches.

Diagnostic Testing for Chronic Migraines

Blood Tests:

1. Complete Blood Count (CBC):

• Importance: Measures levels of different cells in the blood, including red blood cells, white blood cells, and platelets.

• Relationship to Migraines: Abnormalities can indicate conditions like anemia or infections, which can trigger or exacerbate migraines.

2. Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP):

• Importance: Markers of inflammation.

• Relationship to Migraines: Elevated levels can indicate chronic inflammation, which is associated with migraines.

3. Thyroid Function Tests (T3, T4, TSH):

• Importance: Assess thyroid gland function.

• Relationship to Migraines: Both hypo- and hyperthyroidism can cause headaches and migraines due to their effects on metabolism and blood flow.

4. Electrolyte Panel:

• Importance: Measures levels of key electrolytes.

• Relationship to Migraines: Imbalances, especially low magnesium levels, are linked to migraine development.

5. Liver Function Tests (LFTs):

• Importance: Evaluate liver health.

• Relationship to Migraines: Liver dysfunction can lead to toxin buildup, affecting brain function and causing migraines.

6. Kidney Function Tests (BUN, Creatinine):

• Importance: Assess kidney function.

• Relationship to Migraines: Impaired kidney function can lead to waste product accumulation and electrolyte imbalances, triggering headaches and migraines.

7. Vitamin D Levels:

• Importance: Measure vitamin D in the blood.

• Relationship to Migraines: Deficiency has been linked to increased frequency of migraines due to its role in reducing inflammation and maintaining neurological health.

8. Vitamin B12 and Folate Levels:

• Importance: Measure levels of vitamin B12 and folate.

• Relationship to Migraines: Deficiencies can lead to neurological symptoms and headaches due to their roles in nerve function and red blood cell production.

9. Magnesium Levels:

• Importance: Measure magnesium in the blood.

• Relationship to Migraines: Low magnesium levels are common in individuals with migraines and can cause hyperexcitability of neurons and vasospasm.

Imaging Studies:

1. Magnetic Resonance Imaging (MRI):

• Importance: Rule out structural brain abnormalities, tumors, or lesions.

• Relationship to Migraines: Helps identify any physical issues that could be causing migraines.

2. Computed Tomography (CT) Scan:

• Importance: Check for bleeding, tumors, or other structural issues.

• Relationship to Migraines: Useful for ruling out serious causes of headaches.

3. Magnetic Resonance Angiography (MRA):

• Importance: Evaluate blood vessels in the brain.

• Relationship to Migraines: Identifies abnormalities or aneurysms that could contribute to migraines.

Neurophysiological Tests:

1. Electroencephalogram (EEG):

• Importance: Rule out seizures or other electrical activity abnormalities in the brain.

• Relationship to Migraines: Helps identify underlying neurological issues.

2. Evoked Potentials:

• Importance: Assess the function of visual, auditory, and sensory pathways.

• Relationship to Migraines: Identify abnormalities in sensory processing.

Lumbar Puncture (Spinal Tap):

• Importance: Analyze cerebrospinal fluid (CSF) for infections, bleeding, or other neurological conditions.

• Relationship to Migraines: Helps identify infections or conditions like meningitis that can cause headaches.

Ophthalmologic Examination:

• Importance: Comprehensive eye exam to rule out ocular causes of headaches.

• Relationship to Migraines: Conditions like glaucoma, binocular vision issues or optic neuritis can cause headaches.

Cardiovascular Testing:

1. Echocardiogram:

• Importance: Rule out heart-related issues like patent foramen ovale (PFO).

• Relationship to Migraines: PFO is associated with migraines.

2. Holter Monitor:

• Importance: Evaluate for cardiac arrhythmias.

• Relationship to Migraines: Some arrhythmias are linked to migraines.

Sleep Studies:

1. Polysomnography:

• Importance: Assess for sleep disorders like sleep apnea.

• Relationship to Migraines: Sleep apnea can contribute to chronic migraines.

Neurological Examination:

• Importance: Comprehensive assessment by a neurologist.

• Relationship to Migraines: Identifies any neurological deficits or abnormalities.

Psychiatric Evaluation:

• Importance: Assess for psychological factors like anxiety, depression, or stress.

• Relationship to Migraines: Psychological factors can contribute to chronic migraines.

Autonomic Testing:

• Importance: Evaluate for dysautonomia or other autonomic nervous system disorders.

• Relationship to Migraines: Autonomic dysfunction can be related to migraines.

Medications That Cause Headaches and Migraines as Side Effects

1. Oral Contraceptives (Birth Control Pills):

• Why: Hormonal fluctuations caused by estrogen and progestin can trigger migraines, especially in hormone-sensitive individuals.

2. Nitroglycerin and Other Nitrates:

• Why: Cause vasodilation, increasing blood flow and pressure in the brain.

3. Antihypertensives (e.g., Nifedipine):

• Why: Alter blood vessel tone and blood pressure.

4. Phosphodiesterase Inhibitors (e.g., Sildenafil, Tadalafil):

• Why: Cause vasodilation and increased intracranial pressure.

5. Selective Serotonin Reuptake Inhibitors (SSRIs) (e.g., Fluoxetine, Sertraline):

• Why: Alter serotonin levels, affecting pain pathways and blood vessel tone.

6. Monoamine Oxidase Inhibitors (MAOIs) (e.g., Phenelzine, Tranylcypromine):

• Why: Interactions with certain foods and medications can lead to hypertensive crises.

7. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) (e.g., Ibuprofen, Naproxen):

• Why: Overuse can lead to rebound headaches.

8. Antibiotics (e.g., Doxycycline, Minocycline):

• Why: Direct effects on the central nervous system or increased intracranial pressure.

9. Chemotherapy Agents (e.g., Methotrexate, Cisplatin):Why: Toxic effects on the central nervous system, inflammation, or dehydration.

10. Statins (e.g., Atorvastatin, Simvastatin):

• Why: Alter blood flow or muscle inflammation.

11. Antihistamines (e.g., Diphenhydramine, Loratadine):

• Why: Effects on blood vessels or dehydration.

12. Beta Blockers (e.g., Propranolol, Atenolol):

• Why: Blood pressure changes or individual sensitivity.

13. Corticosteroids (e.g., Prednisone, Dexamethasone):

• Why: Long-term use can increase intracranial pressure.

14. Decongestants (e.g., Pseudoephedrine, Phenylephrine):

• Why: Vasoconstriction and increased blood pressure.

15. Diuretics (e.g., Furosemide, Hydrochlorothiazide):

• Why: Dehydration and electrolyte imbalances.

Conditions Increasing Venous Pressure Leading to Migraines

1. Sudden Rapid Weight Loss:

• Mechanism: Severe caloric restriction or dehydration alters CSF dynamics and venous pressure.

• Impact on Migraines: Triggers migraines due to changes in intracranial pressure and brain sensitivity.

2. Idiopathic Intracranial Hypertension (IIH):

• Mechanism: Increased intracranial pressure without an obvious cause, often associated with reduced venous outflow and increased CSF production.

• Impact on Migraines: Mimics migraines with symptoms like visual disturbances.

3. Chronic Obstructive Pulmonary Disease (COPD):

• Mechanism: Chronic hypoxia and increased pulmonary artery pressure lead to elevated central venous pressure.

• Impact on Migraines: Alters cerebral blood flow and increases intracranial pressure, triggering migraines.

4. Venous Sinus Thrombosis:

• Mechanism: Blood clot in the brain’s venous sinuses obstructs venous outflow and increases intracranial pressure.

• Impact on Migraines: Causes severe headaches similar to migraines.

5. Heart Failure:

• Mechanism: Poor cardiac output and fluid retention increase central venous pressure.

• Impact on Migraines: Elevated venous pressure affects cerebral venous pressure and intracranial pressure.

6. Obesity:

• Mechanism: Increased abdominal pressure leads to increased central venous pressure and risk of IIH.

• Impact on Migraines: Changes in CSF dynamics and intracranial pressure trigger migraines.

7. Sleep Apnea:

• Mechanism: Intermittent hypoxia and increased intrathoracic pressure during apneic episodes.

• Impact on Migraines: Hypoxia and pressure changes contribute to headaches and migraines.

8. Superior Vena Cava Syndrome:

• Mechanism: Obstruction of the superior vena cava increases venous pressure in the upper body.

• Impact on Migraines: Increased venous pressure affects cerebral venous outflow and intracranial pressure.

9. Hormonal Changes:

• Mechanism: Fluid retention and blood volume changes increase venous pressure.

• Impact on Migraines: Hormonal changes exacerbate migraines by altering venous pressure and fluid dynamics.

10. Dehydration:

• Mechanism: Reduces blood volume, leading to compensatory mechanisms that increase venous pressure and intracranial pressure.

• Impact on Migraines: Dehydration disrupts normal blood flow and increases venous pressure in the brain.

Final Thoughts

Headaches and migraines are complex conditions with various underlying causes and triggers. Identifying these causes through comprehensive diagnostic testing and understanding their pathophysiology is crucial for effective management and treatment.

At Movability, our expert team specializes in uncovering the root causes of your headaches and migraines. By employing a collaborative approach, our practitioners conduct thorough history and physical examinations, complemented by essential testing. This ensures you receive the personalized treatment you need to reclaim your life.

Understanding the intricacies of the body allows us to tailor the most effective strategies for relief and prevention. Don’t let chronic headaches and migraines control your life. Visit Movability for a comprehensive evaluation and embark on a journey towards lasting relief. Let us help you get back to living your best life.