Comprehensive Guide to the Anatomy and Pathologies of Radial, Ulnar, and Median Nerves

The nervous system is essential for sensory and motor functions in the human body, particularly in the upper limbs. The radial, ulnar, and median nerves play critical roles in hand and arm movements, and understanding their anatomy and pathologies is vital for effective diagnosis and treatment. This article delves into the detailed anatomy of these nerves, the muscles they innervate, common pathologies affecting them, their biomechanical functions, and how other conditions like brachial plexus entrapment and cervical radiculopathy can mimic their symptoms.

Radial Nerve Anatomy and Pathologies

Anatomy

The radial nerve originates from the brachial plexus, specifically from nerve roots C5 to T1. It travels posteriorly down the arm, encircling the humerus in the spiral groove, then moves anteriorly near the elbow and continues down the forearm. It innervates the triceps brachii, anconeus, brachioradialis, extensor carpi radialis longus and brevis, extensor digitorum, extensor digiti minimi, extensor carpi ulnaris, supinator, abductor pollicis longus, extensor pollicis brevis and longus, and extensor indicis. It provides sensory feedback from the posterior arm, forearm, and hand.

Pathologies

Radial Neuropathy (Saturday Night Palsy): Typically caused by prolonged compression; symptoms include wrist drop and numbness.

Humeral Fractures: Direct trauma leading to similar symptoms due to nerve compression.

Crutch Palsy: From extended crutch use, leading to wrist drop and sensory deficits.

Radial Tunnel Syndrome: Compression at the forearm causing pain with finger extension.

Posterior Interosseous Nerve Syndrome: Affects a deep branch, leading to motor deficits without sensory loss.

Ulnar Nerve Anatomy and Pathologies

Anatomy

The ulnar nerve arises from the C8 and T1 nerve roots, descending along the arm’s medial aspect, wrapping around the medial epicondyle at the elbow, and continuing into the forearm and hand. It innervates the flexor carpi ulnaris and part of the flexor digitorum profundus. In the hand, it supplies most intrinsic muscles, excluding the thenar muscles and lateral two lumbricals, and provides sensation to the ulnar hand and fingers.

Pathologies

Cubital Tunnel Syndrome: Compression at the elbow causes numbness in the ulnar fingers and muscle atrophy.

Guyon’s Canal Syndrome: Compression in the wrist’s Guyon’s canal; similar symptoms but without forearm involvement.

Ulnar Nerve Entrapment at the Wrist: Compression leading to hand muscle weakness and sensory disturbances.

Median Nerve Anatomy and Pathologies

Anatomy

Formed from roots C5 to T1, the median nerve runs down the middle of the arm to the hand through the carpal tunnel. It innervates the pronator teres, flexor carpi radialis, palmaris longus, flexor digitorum superficialis, lateral portion of flexor digitorum profundus, flexor pollicis longus, pronator quadratus, thenar muscles, and lateral two lumbricals. It provides sensation to the palm and fingers except for the little finger.

Pathologies

Carpal Tunnel Syndrome: Caused by compression in the carpal tunnel, leading to numbness, tingling, and pain in the thumb to ring fingers.

Pronator Teres Syndrome: Compression at the forearm causing similar symptoms, but localized more proximally.

Anterior Interosseous Nerve Syndrome: Affects a branch of the median nerve, leading to weakness in thumb and finger flexion, typically without sensory symptoms.

Biomechanical Functions of Radial, Ulnar, and Median Nerves

Each of these nerves has specific biomechanical roles that are crucial for hand and arm function:

• Radial Nerve: Essential for extension of the wrist and fingers, allowing for movements like releasing objects or performing a backhand in tennis.

• Ulnar Nerve: Facilitates complex hand movements such as grip and fine motor control, crucial for tasks requiring precision like typing or playing a musical instrument.

• Median Nerve: Primarily involved in thumb opposition, flexion of the wrist and fingers, and tactile sensation across the palm, enabling activities such as writing and gripping.

Brachial Plexus Entrapment and Cervical Radiculopathy as Mimics of Peripheral Nerve Pathology

Brachial Plexus Entrapment

The brachial plexus is a network of nerves that sends signals from the spinal cord to the shoulder, arm, and hand. Entrapment of this plexus can occur due to several reasons such as trauma, repetitive stress, or anatomical variations like a cervical rib. The symptoms can mimic those of radial, ulnar, or median nerve pathologies because the brachial plexus contains the roots and trunks that give rise to these nerves. Common symptoms include pain, weakness, and sensory changes in the shoulder, arm, or hand. The entire arm may be affected, which can make it challenging to differentiate from specific nerve injuries without detailed imaging and nerve conduction studies.

Cervical Radiculopathy

Cervical radiculopathy occurs when one or more nerve roots in the cervical spine are compressed or irritated. This condition can mimic peripheral nerve pathologies because the symptoms include pain, weakness, and numbness in a pattern that often overlaps with the distributions of the median, ulnar, or radial nerves. For example, radiculopathy involving the C6 nerve root can produce symptoms similar to those of carpal tunnel syndrome (median nerve compression), while C8 or T1 radiculopathy might mimic ulnar nerve entrapment symptoms.

Diagnostic Considerations

To differentiate between these conditions, healthcare providers may use specific tests such as:

• Spurling’s Test: This test involves lateral bending and axial compression of the neck to see if it exacerbates the symptoms, suggesting cervical radiculopathy.

• Tinel’s Sign and Phalen’s Test: Commonly used to assess carpal tunnel syndrome but can help in assessing if the symptoms are localized to the wrist or more proximal, which may suggest a cervical or brachial plexus origin.

• Electromyography (EMG) and Nerve Conduction Studies (NCS): These tests can help pinpoint the location of nerve dysfunction and distinguish between nerve root, brachial plexus, and specific peripheral nerve issues.

Common Signs and Symptoms of Pinched Nerves: From Mild to Severe

Pinched nerves occur when excessive pressure is applied to a nerve by surrounding tissues, such as bones, cartilage, muscles, or tendons. This pressure disrupts the nerve’s function, leading to various symptoms, which can range from mild to severe depending on the extent of the compression and the duration for which the nerve has been compressed. Here’s how these symptoms can progress:

Mild Symptoms

In the initial stages of nerve compression, the signs and symptoms are often mild and may come and go. Common mild symptoms include:

• Numbness or Decreased Sensation: In the area supplied by the nerve.

• Tingling or “Pins and Needles”: A feeling akin to a limb “falling asleep.”

• Mild Pain: A sharp or burning pain that may radiate outward.

These symptoms might initially be intermittent, often noticed when certain activities are performed that exacerbate the nerve compression.

Moderate Symptoms

If the pressure on the nerve continues without relief, symptoms can progress to a moderate level where they become more persistent and interfere with daily activities:

• Persistent Pain: Stronger and more continuous pain that becomes harder to ignore.

• Muscle Weakness: Affected muscles may start to show signs of weakness, making it difficult to perform certain actions, such as gripping objects or standing up from a seated position.

• Frequent Tingling or Numbness: Occurs more regularly and can significantly affect function in the involved limb.

At this stage, symptoms are more consistent and might not alleviate without changing posture or discontinuing aggravating activities.

Severe Symptoms

Chronic pressure on a nerve can lead to severe and potentially permanent damage if not addressed appropriately:

• Constant Pain: Severe pain that can be debilitating.

• Muscle Atrophy: Lack of muscle use due to pain and weakness can lead to muscle wasting.

• Loss of Function: In severe cases, there may be a noticeable loss of motor function or complete sensory loss in the affected area.

• Neurological Deficits: Severe compression may result in more profound neurological impairments, such as difficulty in coordinating movements or loss of reflexes.

Severe symptoms often indicate significant nerve damage that might require more intensive treatment, such as medical intervention, physical therapy/chiropractic, or even surgery.

Early recognition and treatment of the symptoms of a pinched nerve are crucial to prevent progression and permanent damage. Regular assessments and a proactive approach to treatment and ergonomic adjustments can mitigate the risks associated with nerve compression. If you experience any of these symptoms persistently, it’s advised to consult with a chiropractor or physiotherapist to diagnose the issue and commence appropriate treatment.

Movability’s Approach to Nerve Injury Treatment and Rehabilitation

At Movability, we excel in diagnosing and rehabilitating nerve injuries. Our holistic approach is grounded in detailed orthopedic, neurological, and physical assessments to accurately identify the root causes of nerve compression and related issues. By focusing on both the symptoms and underlying problems, we craft personalized treatment plans that address specific needs, ensuring a comprehensive recovery and enhanced overall well-being. Our patient-centered strategy guarantees the best outcomes, restoring functionality and improving life quality for those suffering from nerve-related conditions.

Sina Yeganeh